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Rockefeller University Press

Response to immune protein determines pathology of multiple sclerosis

Published in Immunotherapy Weekly, October 29th, 2008

New research may help reveal why different parts of the brain can come under attack in patients with multiple sclerosis (MS). According to a new study in mice with an MS-like disease, the brain's response to a protein produced by invading T cells dictates whether it's the spinal cord or cerebellum that comes under fire. The study—from researchers at the University of Maryland School of Medicine in Baltimore and Washington University in St. Louis—will be published online on October 13th in the Journal of Experimental Medicine.

In most MS patients, the disease primarily affects the spinal cord and the white matter of the brain. But a small percentage of patients develop...

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