Immunotherapy Weekly
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Gene Therapy
New gene therapy research reported from National Institutes of Health
November 26th, 2008
"We have devised an ex vivo culture system which generates large numbers of eosinophils at high purity (>90%) from unselected mouse bone marrow progenitors. In response to 4 days of culture with recombinant mouse FLT3-L and recombinant mouse stern cell factor followed by recombinant mouse IL-5 alone thereafter, the resulting bone marrow-derived eosinophils (bmEos) express immunoreactive major basic protein, Siglec F, IL-511 alpha-chain, and transcripts encoding mouse eosinophil peroxidase, CCR3, the IL-3/IL-5/GM-CSF receptor common beta-chain, and the transcription factor GATA-1," scientists writing in the Journal of Immunology report. "BmEos are functionally...
Source: Immunotherapy Weekly (2008-11-26)
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