Immunotherapy Weekly
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Gene Therapy
New research on gene therapy from M.Y. Yan and co-authors summarized
November 26th, 2008
"PAX5 is a member of the PAX family of developmental transcription factors with an important role in B-cell development. Its expression in normal adult tissue is limited to the hemopoietic system, but it is aberrantly expressed in a number of solid cancers and leukemias where it functions as an oncogene," scientists in London, the United Kingdom report. "We therefore hypothesized that anti-PAX5 immune responses could be used to target a number of malignancies without significant toxicity. We screened PAX5 peptides for the ability to bind HLA-A2 and identified a novel sequence, TLPGYPPHV (referred to as TLP). CTL lines against TLP were generated from peripheral blood of...
Source: Immunotherapy Weekly (2008-11-26)
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