Immunotherapy Weekly
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Gene Therapy
Researchers at Osaka University publish new data on gene therapy
November 26th, 2008
"Dendritic cells (DCs) have a critical role in the induction of antigen- specific immune responses, transporting antigens from peripheral tissue to regional lymph nodes where they interact with antigen- specific T lymphocytes. Recent studies revealed that the efficacy of the T cell-dependent immune response depends on the lifespan of the antigen- presenting DCs in the lymph nodes," investigators in Suita, Japan report. "Here, we succeeded in engineering long-lived antigen- presenting DCs via Bcl-x(L)-derived hyperactive mutant antiapoptotic protein ( Bcl-x(FNK)) gene transfer. In a B16BL6 melanoma model, these long-lived DCs exerted potent antitumor immunity that...
Source: Immunotherapy Weekly (2008-11-26)
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