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Immunotherapy Weekly

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HIV/AIDS



New findings in HIV/AIDS described from Drexel University



November 26th, 2008

According to a study from the United States, "The current goal of human immunodeficiency virus type 1 (HIV-1) therapy is to maximally suppress viral replication. Securing this goal requires new drugs and treatment classes."

"The chemokine receptor CCR5 provides an entry portal for HIV-1, and PRO 140 is a humanized monoclonal antibody that binds to CCR5 and potently inhibits CCR5-tropic (R5) HIV-1 in vitro. A randomized, double-blind, placebo-controlled, dose-escalating study was conducted in 39 individuals with HIV-1 RNA levels >= 5000 copies/mL, CD4(+) cell counts >= 250 cells/mu L, no antiretroviral therapy for 3 months, and only R5 HIV-1 detectable. Cohorts...


Source: Immunotherapy Weekly (2008-11-26)

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