Immunotherapy Weekly
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HIV/AIDS
Studies from N. Huarte et al have provided new data on HIV/AIDS
November 26th, 2008
"The broadly neutralizing 2F5 and 4E10 monoclonal antibodies (MAbs) recognize epitopes within the membrane-proximal external region (MPER) that connects the human immunodeficiency virus type 1 (HIV-1) envelope gp41 ectodomain with the transmembrane anchor. By adopting different conformations that stably insert into the virion external membrane interface, such as helical structures, a conserved aromatic-rich sequence within the MPER is thought to participate in HIV-1-cell fusion," researchers in Bilbao, Spain report. "Recent experimental evidence suggests that the neutralizing activity of 2F5 and 4E10 might correlate with the MAbs' capacity to recognize epitopes inserted...
Source: Immunotherapy Weekly (2008-11-26)
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