Immunotherapy Weekly
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Life Sciences
Studies from Veeranna and colleagues yield new information about life sciences
November 26th, 2008
"As axons myelinate, establish a stable neurofilament network, and expand in caliber, neurofilament proteins are extensively phosphorylated along their C-terminal tails, which is recognized by the monoclonal antibody, RT-97. Here, we demonstrate in vivo that RT-97 immunoreactivity (IR) is generated by phosphorylation at KSPXK or KSPXXXK motifs and requires flanking lysines at specific positions. extracellular signal regulated kinase 1,2 (ERK1,2) and pERK1,2 levels increase in parallel with phosphorylation at the RT-97 epitope during early postnatal brain development," scientists writing in the Journal of Neurochemistry report. "Purified ERK1,2 generated RT-97 on...
Source: Immunotherapy Weekly (2008-11-26)
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