Immunotherapy Weekly
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Monoclonal Antibodies
Report summarizes monoclonal antibodies study findings from Harvard University
November 26th, 2008
According to recent research published in the journal Infection and Immunity, "Treatment of ulcerative keratitis due to Pseudomonas aeruginosa is difficult, time-consuming, and uncomfortable owing to the need for the frequent application of antibiotic drops to the infected corneal surface. We examined here whether a fully human immunoglobulin G1 monoclonal antibody (MAb) specific to the conserved alginate surface polysaccharide of P. aeruginosa could mediate protective immunity against typically nonmucoid strains isolated from human cases of keratitis." "MAb F429 effectively opsonized alginate-positive, but not alginate-negative, nonmucoid strains in conjunction...
Source: Immunotherapy Weekly (2008-11-26)
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