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Allergies
Research from T. Yokoi and co-authors reveals new findings on allergies
November 26th, 2008
According to a study from Osaka, Japan, "Allergic diseases such as atopic dermatitis and asthma develop as a consequence of dysregulated T(h)2 responses. Recently, it has been demonstrated that interaction between dendritic cells (DCs) and thymic stromal lymphopoietin (TSLP), an IL-7-like cytokine, is essential for evoking T(h)2 responses in allergy." "In this study, we investigated whether Mycobacterium bovis Bacillus Calmette-Guerin (BCG), a strong T(h)1 response-inducing adjuvant, can alter the function of DCs activated by TSLP (TSLP-DCs). We demonstrated that BCG redirects TSLP-DCs away from inducing inflammatory T(h)2 cells that produce IL-4, IL-5, IL-13 and tumor...
Source: Immunotherapy Weekly (2008-11-26)
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