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Allograft Rejection
Research from Yale University reveals new findings on allograft rejection
November 26th, 2008
According to recent research from the United States, "The pattern recognition receptor, RAGE, has been shown to be involved in adaptive immune responses but its role on the components of these responses is not well understood. We have studied the effects of a small molecule inhibitor of RAG, E. and the deletion of the receptor (RAGE-/- mice) on T cell responses involved in autoimmunity and allograft rejection." "Syngeneic islet graft and islet allograft rejection was reduced in NOD and B6 mice treated with TTP488, a small molecule RAGE inhibitor (p < 0.001). RAGE-/- mice with streptozotocin-induced diabetes showed delayed rejection of islet allografts compared with...
Source: Immunotherapy Weekly (2008-11-26)
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