Immunotherapy Weekly
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Central Nervous System Infection
Reports from Washington University, Medical Department highlight recent research in central nervous system infection
November 26th, 2008
According to recent research from the United States, "West Nile virus (WNV) is a neurotropic flavivirus that has emerged globally as a significant cause of viral encephalitis in humans, especially in immunocompromised individuals. Previous studies have shown essential protective roles for antiviral cytokines (e. g., alpha interferon [IFN-alpha] and IFN-gamma) against WNV in mice." "However, studies using cell culture offer conflicting answers regarding whether tumor necrosis factor alpha (TNF-alpha) has an anti-WNV function. To test the biological significance of TNF-alpha against WNV in vivo, experiments were performed with TNF receptor-1 (TNF-R1)-deficient and...
Source: Immunotherapy Weekly (2008-11-26)
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