Chronic Myelogenous Leukemia

Scientists at Nanjing Medical University describe research in chronic myelogenous leukemia

Published in Immunotherapy Weekly, February 11th, 2009

According to a study from Nanjing, People's Republic of China, "Assay of phosphotyrosine levels using flow cytometry has been used to identify patients with chronic myelogenous leukemia positive for the Bcr-Abl fusion gene. We hypothesized that clinical monitoring could identify treatment response through reductions in intragranulocyte phosphotyrosine."

"Initially, we studied cell lines FDC-P1 and HL60 (Bcr-Abl-negative) and FDrv210 and K562 (Bcr-Abl-positive) with our technique. A fluorescein isothiocyanate-conjugated monoclonal antibody was used along with fluorescence-conjugated microspheres for reference (ratio of sample fluorescence: bead fluorescence=relative...

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Source: Immunotherapy Weekly (2009-02-11)

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