Enzyme Research
Findings in enzyme research reported from Hiroshima University, Department of Pharmacology
Published in Immunotherapy Weekly, February 11th, 2009
A report, 'Phosphorylation of TRPV1 by neurokinin-1 receptor agonist exaggerates the capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons,' is newly published data in Neuropharmacology. According to a study from Japan, "The present study was conducted to determine whether the activation of neurokinin-1 receptor (NK-1R) by its agonist (GR73632) enhances the capsaicin-evoked substance P (SP) release using a radioimmunoassay. A pre-exposure to GR73632 enhanced the capsaicin-evoked SP release in a time-and dose-dependent manner."
"The augmentation of capsaicin-evoked SP release by GR73632 was completely inhibited by pharmacological...
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Source: Immunotherapy Weekly (2009-02-11)
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