Immunotherapy Weekly
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Cancer Gene Therapy
New findings from J.K. Yoon and co-authors in the area of cancer gene therapy published
June 17th, 2009
"We investigated whether theophylline has the potential to increase radioiodide uptake in non-thyroidal cancer cells. MCF-7 cells that express endogenous sodium/iodide symporter (NIS) and SNU-C5 cells adenovirally transduced with the human NIS gene (SNU-C5/NIS) were treated with 10(-7) -2-10(-4) mol/L theophylline for 24 hours before incubation with I-125, and then, radioiodide uptake and retention were measured," scientists in Seoul, South Korea report. "NIS expression was assessed by immunohistochemistry and Western blot analysis, using an antihuman NIS monoclonal antibody. Theophylline at 10(-6) -2x10(-4) mol/L significantly and dose dependently augmented radioiodide...
Source: Immunotherapy Weekly (2009-06-17)
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