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Chronic Lymphocytic Leukemia
University of London publishes research in chronic lymphocytic leukemia
June 17th, 2009
"Preclinical animal models have largely ignored the immune-suppressive mechanisms that are important in human cancers. The identification and use of such models should allow better predictions of successful human responses to immunotherapy," scientists in London, the United Kingdom report. "As a model for changes induced in nonmalignant cells by cancer, we examined T-cell function in the chronic lymphocytic leukemia (CLL) E mu-TCL1 transgenic mouse model. With development of leukemia, E mu-TCL1 transgenic mice developed functional T-cell defects and alteration of gene and protein expression closely resembling changes seen in CLL human patients. Furthermore, infusion of...
Source: Immunotherapy Weekly (2009-06-17)
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