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Drug Resistance
Data on drug resistance described by researchers at University of Missouri
June 17th, 2009
According to recent research published in the Journal of Ocular Pharmacology and Therapeutics, "The purpose of this manuscript is to investigate the presence of nucleoside/nucleotide efflux transporter in cornea and to evaluate the role in ocular drug efflux. RT-PCR, immunoprecipitation followed by Western blot analysis and immunostaining were employed to establish molecular presence of multidrug resistance associated protein 5 (MRP5) on cornea." "Corneal efflux by MRP5 was studied with bis(POM)-PMEA and acyclovir using rabbit and human corneal epithelial cells along with MRP5 over expressing cells (MDCKII-MRP5). Ex vivo studies using excised rabbit cornea and in...
Source: Immunotherapy Weekly (2009-06-17)
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