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Encephalomyelitis
New encephalomyelitis study results reported from Rush University
June 17th, 2009
According to recent research published in the Journal of Immunology, "IL-12p70 (p40:p35) and IL-23 (p40:p19) are bioactive cytokines and their role in experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis, are becoming clear. On the other hand, the IL-12p40 homodimer (p40(2)) was considered as an inactive or inhibitory molecule and its functions are poorly understood." "To facilitate the studies on p40(2), we have recently generated neutralizing mAb against mouse p40(2). The present study demonstrates the effectiveness of p40(2) mAb in treating the disease process of relapsing-remitting EAE in female SJL/J mice. The p40, mAb...
Source: Immunotherapy Weekly (2009-06-17)
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