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Encephalomyelitis
Studies from Mayo Clinic, Medical Department in the area of encephalomyelitis described
June 17th, 2009
According to recent research published in the Journal of Immunology, "Among all of the genetic factors associated with multiple sclerosis (MS) susceptibility, MHC class II molecules have the strongest association. Although a direct role of DR alleles in MS have been confirmed, it has been difficult to understand the role of DQ alleles in disease pathogenesis due to strong linkage disequilibrium with certain DR alleles." "Population studies have indicated that DQ alleles may play a modulatory role in progression of MS. Using HLA class II transgenic (Tg) mice, we investigated gene complementation between DR and DQ genes in the disease process. Previously, using...
Source: Immunotherapy Weekly (2009-06-17)
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