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University of Montreal

Scientists uncover mode of action of enzyme linked with several types of cancer

Scientists at the Institute for Research in Immunology and Cancer (IRIC) of the Universite de Montreal have discovered a key mechanism used by cells to efficiently distribute chromosomes to new cells during cell multiplication. Published in the journal Molecular Cell, the study is the first to demonstrate that this mechanism relies on the polo kinase, an enzyme implicated in several cancers. Inhibiting this mechanism could be key to developing effective therapies to treat cancer.

Each human cell contains, in its nucleus, all the coding instructions necessary to direct the cell's activities. A complete set of those...

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