Glioblastoma

New glioblastoma study findings recently were reported by researchers at University of California

Published in Immunotherapy Weekly, July 1st, 2009

" Chromosome 10q allelic loss commonly occurs in glioblastoma. Disruption of PTEN, one of three known 10q tumor suppressor genes, affects the immune system by increasing tumor expression of immunosuppressive protein B7-H1 and by increasing tumor release of Th2-inducing cytokines," scientists writing in the Journal of Neuro - Oncology report.

"While the former might impair antitumor cellular immunity, a consideration for immunotherapy, the latter could cause 10q-maintaining tumor patients to experience comparatively higher rates of bacterial infections, a source of morbidity and mortality in glioblastoma patients. We retrospectively reviewed 58 glioblastoma...

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Source: Immunotherapy Weekly (2009-07-01)

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