Immunotherapy Weekly
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Colon Cancer
New colon cancer study results reported from E.M. Levy et al
July 8th, 2009
According to a study from Buenos Aires, Argentina, "Cetuximab, an anti-epidermal growth factor receptor monoclonal antibody, has been shown to increase the median survival of colorectal cancer patients. We previously reported that the expression of HLA-E is significantly increased in primary human colorectal cancer, perhaps contributing to tumour escape from immune surveillance." "To establish if HLA-E could be a factor that renders colorectal cancer cells less susceptible to antibody-dependent cellular cytotoxicity (ADCC), in the present study we analysed Cetuximab-mediated cytotoxicity against several colorectal cancer cell lines expressing, or not, HLA-E at the cell...
Source: Immunotherapy Weekly (2009-07-08)
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