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Viral Immunology
Researchers from University of Pennsylvania, Medical Department describe findings in viral immunology
July 15th, 2009
According to recent research from the United States, "Neutralizing antibodies are thought to be required at mucosal surfaces to prevent human papillomavirus (HPV) transmission. However, the potential for cell-mediated immunity in mediating protection against HPV infection has not been well explored." "We generated recombinant Listeria monocytogenes (Lm) constructs that secrete listeriolysin O (LLO) fused with overlapping N-terminal (LLO-L1(1-258)) or C-terminal (LLO-L1(238-474)) fragments of HPV type 16 major capsid protein L1 (HPV-16-L1). Oral immunization of mice with either construct induced IFN-gamma-producing CD8(+) and CD4(+) T cells in the spleen and in the...
Source: Immunotherapy Weekly (2009-07-15)
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