Angiogenesis

Research data from Vrije University Amsterdam update understanding of angiogenesis

Published in Immunotherapy Weekly, August 5th, 2009

"Tumours express tumour-associated antigens that are recognised as self-antigens precluding the induction of effective antitumour immune responses. Inflammatory conditions which facilitate appropriate antigen presentation and reduce the immuno-suppressive micro-milieu may break tolerance," investigators in Amsterdam, Netherlands report.

"However, tumours have evolved mechanisms to escape cytotoxic T-cell attack by expressing inhibitory molecules on their surface, secreting suppressive factors, attracting regulatory T cells to the tumour environment or downregulating MHC molecules. Induction of angiogenesis by tumours may represent another mechanism by which tumours...

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Source: Immunotherapy Weekly (2009-08-05)

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