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Angiogenesis

Studies from M. Kulka et al further understanding of angiogenesis

Published in Immunotherapy Weekly, December 23rd, 2009

According to a study from Charlottetown, Canada, "ANG is a plasma protein with angiogenic and ribonucleolytic activity implicated in tumor growth, heart failure, wound healing, asthma, and the composition of the adult gut microflora. Human mast cells (HuMC) are similarly associated with modulation of vascular permeability, angiogenic processes, wound healing, and asthma."

"We hypothesized that HuMC express and secrete ANG in response to divergent stimuli. ANG expression was evaluated in the LAD2 HMC, the HMC-1, and CD34(+)-derived HuMC, following exposure to live Escherichia coli, TLR ligands, or neuropeptides and following Fc epsilon RI aggregation. Expression and...

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