Published in Immunotherapy Weekly, January 6th, 2010
"We developed a mouse monoclonal antibody targeting the IDH1 R132H mutation. Here, we show the high specificity and sensitivity of this antibody on Western blots and tissue sections from formalin fixed paraffin embedded tumor specimens," wrote D. Capper and colleagues, University of Heidelberg.
The researchers concluded: "This antibody is highly useful for tumor classification, in detecting single infiltrating tumor cells and for the characterization of the cellular role of mutant IDH1 protein."
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