Leukemia Immunology

New leukemia immunology study findings have been reported from University Medical Center, Department of Medicine

Published in Immunotherapy Weekly, January 27th, 2010

A new study, 'Single-cell analysis reveals oligoclonality among 'low-count' monoclonal B-cell lymphocytosis,' is now available. "Monoclonal B-cell lymphocytosis (MBL) is a preclinical hematologic syndrome characterized by small accumulations of CD5(+) B lymphocytes. Most MBL share phenotypic characteristics with chronic lymphocytic leukemia (CLL)," scientists in the United States report.

"Although some MBL progress to CLL, most MBL have apparently limited potential for progression to CLL, particularly those MBL with normal absolute B-cell counts ('low-count' MBL). Most CLL are monoclonal and it is not known whether MBL are monoclonal or oligoclonal; this is important...

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Source: Immunotherapy Weekly (2010-01-27)

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