Molecular Immunology

New molecular immunology study findings have been reported by K. Jozaki and co-researchers

Published in Immunotherapy Weekly, February 24th, 2010

According to a study from Tsukuba, Japan, "Nucleotide oligomerization domain 2 (NOD2) is a cytosolic pattern recognition receptor (PRR) that responds to muramyldipeptide (MDP), a component of peptidoglycans of Gram positive and negative bacteria. NOD2 is involved in the modulation of signaling pathways for other PRRs, such as Toll-like receptors."

"Polymorphisms in NOD2 may evoke bowel disorders, and human Crohn's disease is significantly correlated with mis-sense insertion of the NOD2 gene. Such polymorphisms affecting ligand recognition in the NOD2 gene may also influence bowel flora in livestock, which is compromised by bowel diseases such as diarrhea. We...

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Source: Immunotherapy Weekly (2010-02-24)

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