Eosinophilia

Scientists at Cleveland Clinic describe research in eosinophilia

Published in Immunotherapy Weekly, June 2nd, 2010

"Eosinophilic inflammation is closely related to angiogenesis in asthmatic airway remodeling. In ovalbumin (OVA) sensitized mice bone marrow derived, proangiogenic endothelial progenitor cells (EPCs) are rapidly recruited into the lungs after OVA aerosol challenge and promptly followed by mobilization and recruitment of eosinophils," scientists in the United States report.

"We hypothesized that bone marrow derived EPCs initiate the recruitment of eosinophils through expression of the eosinophil chemoattractant eotaxin-1. EPCs were isolated from an OVA murine model of allergic airway inflammation and from asthmatic patients. Endothelial and smooth muscle cells were...

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Source: Immunotherapy Weekly (2010-06-02)

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