Nucleoproteins
New nucleoproteins research reported from University of Gottingen, Center for Molecular Biosciences
Published in Immunotherapy Weekly, June 2nd, 2010
A new study, 'Induced G1 cell-cycle arrest controls replication-dependent histone mRNA 3' end processing through p21, NPAT and CDK9,' is now available. According to recent research from Germany, "Proper cell cycle-dependent expression of replication-dependent histones is essential for packaging of DNA into chromatin during replication. We previously showed that cyclin-dependent kinase-9 (CDK9) controls histone H2B monoubiquitination (H2Bub1) to direct the recruitment of specific mRNA 3' end processing proteins to replication-dependent histone genes and promote proper pre-mRNA 3' end processing."
"We now show that p53 decreases the expression of the histone-specific...
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Source: Immunotherapy Weekly (2010-06-02)
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