Chagas Disease
Federal University of Minas Gerais details research in Chagas disease
Published in Immunotherapy Weekly, January 12th, 2011
2011 JAN 12 -- "The anti-hypertensive drug captopril is used commonly to reduce blood pressure of patients with severe forms of Chagas disease, a cardiomyopathy caused by chronic infection with the intracellular protozoan Trypanosoma cruzi. Captopril acts by inhibiting angiotensin-converting enzyme (ACE), the vasopressor metallopeptidase that generates angiotensin II and promotes the degradation of bradykinin (BK)," scientists in Belo Horizonte, Brazil report.
"Recent studies in mice models of Chagas disease indicated that captopril can potentiate the T helper type 1 (Th1)-directing natural adjuvant property of BK. Equipped with kinin-releasing cysteine...
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Source: Immunotherapy Weekly (2011-01-12)
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