Rheumatoid Arthritis
Findings in Rheumatoid Arthritis Reported from Karolinska University Hospital
Published in Immunotherapy Weekly, January 11th, 2012
2012 JAN 11 -- "In addition to its direct proinflammatory activity, extracellular high mobility group box protein 1 (HMGB1) can strongly enhance the cytokine response evoked by other proinflammatory molecules, such as lipopolysaccharide (LPS), CpG-DNA and IL-1 beta, through the formation of complexes. Extracellular HMGB1 is abundant in arthritic joint tissue where it is suggested to promote inflammation as intra-articular injections of HMGB1 induce synovitis in mice and HMGB1 neutralizing therapy suppresses development of experimental arthritis," researchers in Stockholm, Sweden report.
"The aim of this study was to determine whether HMGB1 in complex with...
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Source: Immunotherapy Weekly (2012-01-11)
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