Mayo Clinic

MAPK pathway may be a potential therapeutic target in ALL

Published in Lab Business Week, January 12th, 2004

The MAPK pathway may be a potential therapeutic target in acute lymphocytic leukemia (ALL).

According to recent research published in the Journal of Biological Chemistry, "Because the MAPK pathway plays important roles in cell proliferation and inhibition of apoptosis, this pathway has emerged as a potential therapeutic target for solid tumors and leukemia.

"At the present time there is little information about activation of this pathway and the consequences of its inhibition in acute lymphocytic leukemia (ALL) cells. In the present study, constitutive MAPK pathway activation, as evidenced by phosphorylation of ERK1 and ERK2, was observed in 8...

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Source: Lab Business Week (2004-01-12)

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