Istituto Superiore di Sanita
HIV Nef induces DC differentiation through Vav signaling
Published in Lab Business Week, January 12th, 2004
"The accessory HIV-1 Nef protein plays a key role in AIDS pathogenesis," scientists in Italy explained.
"We recently demonstrated that exogenous Nef triggers phenotypic and functional differentiation of immature dendritic cells (DCs)," according to M.G. Quaranta and colleagues at the Istituto Superiore di Sanita in Rome. In a subsequent study, they "investigated whether the Nef-induced DC differentiation occurs with morphological remodeling," focusing on "the interference of Nef in the signaling pathways that regulates DC maturation."
The researchers "found that...
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Source: Lab Business Week (2004-01-12)
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