Kanazawa University
The carboxyl-terminal half of ADAMTS-1 diminishes metastatic potential
Published in Lab Business Week, September 5th, 2004
"ADAMTS-1 is an extracellular matrix (ECM)-anchored metalloproteinase with proteoglycan-degrading activity as well as an angiogenesis inhibiting activity. Here, we examined the effects of ADAMTS-1 overexpression on in vivo tumor growth and tumor metastasis. Overexpression of only the C-terminal half region of ADAMTS-1, consisting of thrombospondin (TSP) type I motifs and the spacer region, suppressed Chinese hamster ovary (CHO) tumor growth in mice," researchers in Japan report.
"In addition, a significant reduction in tumor metastatic potential was observed in...
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Source: Lab Business Week (2004-09-05)
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