University of Colorado
HIV-1 Tat regulates SOD2 basal promoter by altering Sp1/Sp3 binding activity
Published in Lab Business Week, November 21st, 2004
"Regulation of the basal manganese superoxide dismutase (SOD2) promoter depends on the transcriptional activity of the Sp family of transcription factors.
"We report that reduced expression in the presence of Tat is independent of induction with tumor necrosis factor a and that Tat affects the interaction of Sp1 and Sp3 with the basal promoter," wrote scientists in the journal Free Radical Biology and Medicine.
"Footprinting and electrophoretic mobility shift assay (EMSA) analyses with extracts from HeLa cells showed that Sp1/Sp3 complexes...
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Source: Lab Business Week (2004-11-21)
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