York University, Toronto

Mechanism of Nodal's protective effects elucidated in vitro

Published in Lab Business Week, January 23rd, 2005

A recent study from York University in Toronto investigated the Nodal gene's mechanism of action in ovarian cancer.

"Human epithelial ovarian cancer is the most lethal female cancer. Hormones and growth factors, including the tumor growth factor (TGF)-beta superfamily, have been suggested to play a role in ovarian tumorigenesis. The biological effects of TGF-beta superfamily are mediated by type I and type II serine/threonine kinase receptors and by intracellular Smad proteins," said G.X. Xu and colleagues.

"Recently, we have cloned four transcripts of human activin receptor-like kinase 7 (ALK7), a type I receptor for Nodal. In this study, we have...

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Source: Lab Business Week (2005-01-23)

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