Published in Lab Business Week, January 23rd, 2005
"Human epithelial ovarian cancer is the most lethal female cancer. Hormones and growth factors, including the tumor growth factor (TGF)-beta superfamily, have been suggested to play a role in ovarian tumorigenesis. The biological effects of TGF-beta superfamily are mediated by type I and type II serine/threonine kinase receptors and by intracellular Smad proteins," said G.X. Xu and colleagues.
"Recently, we have cloned four transcripts of human activin receptor-like kinase 7 (ALK7), a type I receptor for Nodal. In this study, we have...
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