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Mayo Clinic, Rochester

Midodrine improves the recovery of beat-to-beat BP after exercise

Published in Lab Business Week, January 30th, 2005

Researchers have investigated the effects of midodrine on exercise-induced hypotension and blood pressure recovery in autonomic failure.

According to a study from the United States, "We tested the hypothesis that the oral alpha1 -adrenergic agonist, midodrine, would limit the fall in arterial pressure observed during exercise in patients with pure autonomic failure (PAF)."

W.G. Schrage and colleagues of the Mayo Clinic described their study, "Fourteen subjects with PAF underwent a stand test, incremental supine cycling exercise (25, 50, and 75 W), and ischemic calf exercise, before (control) and 1 hour after ingesting 10 mg midodrine....

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