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University of Oxford

New data illuminates research in tuberculosis vaccines

Published in Lab Business Week, February 20th, 2005

Data on tuberculosis vaccines are outlined in reports from the United Kingdom, Kuwait and France.

Study 1: Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans.

According to recent research published in the journal Nature Medicine, "Protective immunity against Mycobacterium tuberculosis depends on the generation of a Th1-type cellular immune response, characterized by the secretion of interferon-gamma (IFN-gamma) from antigen-specific T cells. The induction of potent cellular immune responses by vaccination in humans has proven difficult....

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