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University of Ioannina

NEUROD1 gene polymorphism and diabetes susceptibility investigated

Published in Lab Business Week, May 1st, 2005

Researchers examine the Ala45Thr polymorphism of the NEUROD1 gene and diabetes susceptibility in a recent issue of Human Genetics.

"A meta-analysis assessed whether the Ala45Thr polymorphism of the neurogenic differentiation 1 (NEUROD1) gene is associated with increased risk of diabetes mellitus type 1 (T1D) or type 2 (T2D). Fourteen case-control studies were analyzed, including genotype data on 3,057 patients with diabetes (T1D n=1,213, T2D n=1,844) and 2,446 controls. Overall and race-specific summary odds ratios (ORs) were obtained with fixed and random effects models," scientists in Greece report.

"The Thr allele did not significantly...

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