University of Minnesota
Cyclosporine is toxic in immunosuppressed diabetic nonhuman primates
Published in Lab Business Week, May 1st, 2005
According to a study from the United States, "Streptozotocin (STZ) is widely applied in animal models of insulin-dependent diabetes mellitus. Adverse effects of STZ mainly concern liver and kidney. In nonhuman primates a single 100 to 150 mg/kg dose invariably induces diabetes with only rare adverse effects. We report one animal with renal failure necessitating sacrifice. Body weight (age) might be a confounding factor (i.e., older animals might be more vulnerable to STZ-related toxicity). We therefore recommended to administer STZ on a mg/m2 basis and not on a mg/kg...
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Source: Lab Business Week (2005-05-01)
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