Chinese Academy of Science, Shanghai
SARS CoV 3CL(pro) indispensable for proteolytic activity/not enzyme dimerization
Published in Lab Business Week, May 29th, 2005
According to published research from People's Republic of China, "Severe acute respiratory syndrome (SARS) coronavirus is a novel human coronavirus and is responsible for SARS infection. SARS coronavirus 3C-like proteinase (SARS 3CL(pro)) plays key roles in viral replication and transcription and is an attractive target for anti-SARS drug discovery.
"In this report, we quantitatively characterized the dimerization features of the full-length and N-terminal residues 1-7 deleted SARS 3CL(pro)s by using glutaraldehyde cross-linking SDS-PAGE, size-exclusion...
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Source: Lab Business Week (2005-05-29)
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