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University of Valencia

Captopril normalizes adrenergic intracellular Ca2+ handling in rats

Published in Lab Business Week, May 29th, 2005

Captopril - but not other antihypertensive agents - normalizes adrenergic intracellular Ca2+ handling in rats.

In a study from Spain, the "effect of hypertension and acute (36-h) or chronic (from age 6 to 16 weeks) antihypertensive treatment with prazosin (2 mg/kg per day), nifedipine (50 mg/kg per day), or captopril (50 mg/kg per day) on Ca2+ mobilization due to alpha1 -adrenoceptor activation was analyzed."

R. Miquel and coauthors at the University of Valencia conducted functional experiments "using arterial rings [four conductance/distributing vessels: aorta, main mesenteric, iliac, and tail arteries and two...

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