University of Pittsburgh

Brain injury studied, enhanced oxidative stress in iNOS-deficiency shown

Published in Lab Business Week, July 17th, 2005

A study for the United States has reported on enhanced oxidative stress in inducible nitric oxide synthase (iNOS)-deficient mice after traumatic brain injury (TBI).

"Studies in experimental TBI suggests both deleterious and protective effects of iNOS. Early after injury, iNOS may be detrimental via formation of peroxynitrite and iNOS inhibitors are protective. In contrast, we reported impaired long-term functional outcome after TBI in iNOS knockout (ko) versus wild-type (wt) mice," wrote H. Bayir and colleagues, University of Pittsburgh.

"To elucidate potential neuroprotective and neurotoxic mechanisms for iNOS we studied nitric oxide formation by...

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Source: Lab Business Week (2005-07-17)

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