Foundation Inst. of Immunology of Colombia, Bogota

Two L1-peptides help detect HPV-associated lesions

Published in Lab Business Week, July 17th, 2005

According to a report from Colombia, "A persistent high-risk human papillomavirus (HR-HPV) infection causes cervical intraepithelial lesions and cervical carcinoma.

"There is evidence that detecting anti-L1 antibodies could be successfully used for discriminating between cervical lesion patients and women having normal cytology."

M. Urquiza and colleagues at the Foundation Institute of Immunology of Colombia "found that peptides 18283 ((55)PNNNKILVPKVSGLQYRVFR(74)) and 18294 ((284)LYIKGSGSTANLASSNYFPT(300)) from the L1-surface exposed regions were specifically recognized by antibodies from the cervical lesion patient sera. These peptides were tested...

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Source: Lab Business Week (2005-07-17)

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