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VA Medical Center Long Beach

Intestinal niacin uptake examined, mechanism and regulation defined

Published in Lab Business Week, August 14th, 2005

A study from the United States has defined the mechanism and regulation of human intestinal niacin uptake.

"The mechanism of uptake of dietary niacin (nicotinic acid) by intestinal epithelial cells is not well understood, and nothing is known about regulation of the uptake process. In this investigation, we used human-derived intestinal epithelial Caco-2 cells and purified intestinal brush-border membrane vesicles (BBMVs) isolated from human organ donors to assess niacin uptake," wrote S.M. Nabokina and colleagues, Veterans Affairs Medical Center.

"Our findings show niacin uptake by Caco-2 cells to be

1) temperature and energy...

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