Published in Lab Business Week, August 28th, 2005
"C5b-9-induced GEC injury in vivo (in passive Heymann nephritis) and in culture is associated with damage to the ER and increased expression of ER stress proteins. Induction of ER stress proteins is enhanced via cytosolic phospholipase A2 (cPLA2 ) and limits complement-dependent cytotoxicity," wrote A.V. Cybulsky and colleagues, Royal Victoria Hospital.
"The present study addresses another aspect of the ER unfolded protein response, i.e. activation of protein kinase R-like ER...
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