Royal Victoria Hospital, Montreal

Glomerular epithelial cell injury studied, role of ER protein shown

Published in Lab Business Week, August 28th, 2005

A study from Canada has reported on the role of the endoplasmic reticulum (ER) unfolded protein response in glomerular epithelial cell injury (GEC).

"C5b-9-induced GEC injury in vivo (in passive Heymann nephritis) and in culture is associated with damage to the ER and increased expression of ER stress proteins. Induction of ER stress proteins is enhanced via cytosolic phospholipase A₂ (cPLA₂ ) and limits complement-dependent cytotoxicity," wrote A.V. Cybulsky and colleagues, Royal Victoria Hospital.

"The present study addresses another aspect of the ER unfolded protein response, i.e. activation of protein kinase R-like ER...

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Source: Lab Business Week (2005-08-28)

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