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University of Massachusetts, Worcester

Nonribosomal landscape in nucleolus revealed by stem cell protein nucleostemin

Published in Lab Business Week, September 11th, 2005

A nonribosomal landscape in the nucleolus is revealed by the stem cell protein nucleostemin.

According to a study from the United States, "Nucleostemin is a p53-interactive cell cycle progression factor that shuttles between the nucleolus and nucleoplasm, but it has no known involvement in ribosome synthesis.

"We found the dynamic properties of nucleostemin differed strikingly from fibrillarin (a protein directly involved in rRNA processing) both in response to rRNA transcription inhibition and in the schedule of reentry into daughter nuclei and the nucleolus during late telophase/early G(1)."

"Furthermore," said the authors,...

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