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University of Leipzig

Presence of PIF in urine did not predict malignancy of pancreatic tumor

Published in Lab Business Week, October 9th, 2005

The presence of proteolysis-inducing factor (PIF) in urine did not predict malignancy of a pancreatic tumor.

According to recent research from Germany, "The proteolysis-inducing factor (PIF) was identified as a tumor product in various gastrointestinal cancers. A previous study in pancreatic cancer patients suggested PIF expression as a tumor marker, which is not related to tumor size."

"We hypothesized that PIF could be a useful marker to exclude benign pancreatic tumors, as chronic pancreatitis with a pancreatic mass. Urine of patients with a pancreatic mass of uncertain malignancy was investigated for PIF expression by Western blot," explained N....

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