MRC Dunn Human Nutrition Unit, Cambridge
New data illuminates research in proteomics
Published in Lab Business Week, December 25th, 2005
Study 1: Data from isolated skeletal muscle mitochondria indicate that uncoupling protein 3 protects aconitase against inactivation.
"Mitochondrial uncoupling proteins only catalyze proton transport when they are activated. Activators include superoxide and reactive alkenals, suggesting new physiological functions for UCP2 and UCP3: their activation by superoxide when protonmotive force is high causes mild uncoupling, which lowers protonmotive force and attenuates superoxide generation by the electron transport chain," scientists writing in the journal...
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Source: Lab Business Week (2005-12-25)
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