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University of Delhi

Interferon-alpha and lamivudine combination yields higher therapeutic efficacy

Published in Lab Business Week, December 25th, 2005

A study from India has reported higher efficacy of sequential therapy with interferon-alpha and lamivudine combination compared to lamivudine monotherapy in HBeAg positive chronic hepatitis B (CHB) patients.

"Monotherapy with interferon (IFN) or lamivudine is effective in a limited proportion of CHB patients. A sequential combination may have better therapeutic effects by sustained viral suppression combined with immunomodulation," wrote S.K. Sarin and colleagues, University of Delhi.

"To compare the efficacy of sequential lamivudine and IFN therapy versus lamivudine monotherapy in HBeAg positive CHB patients, 75 treatment naive HBeAg positive...

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